SML3837
WEHI-9625
≥98% (HPLC)
Synonym(s):
7-(2-(4-methoxybenzoyl)phenyl)-N-(4-methylbenzyl)-4H-thieno[3,2-c]thiochromene-2-carboxamide 5,5-dioxide, WEHI 9625
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About This Item
Empirical Formula (Hill Notation):
C34H27NO5S2
CAS Number:
Molecular Weight:
593.71
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
VDAC2 ligand that enhances VDAC2:BAK interaction and selectively blocks murine BAK-mediated apoptosis.
WEHI-9625 is a VDAC2 ligand that enhances VDAC2:BAK interaction and selectively blocks murine BAK-mediated apoptosis in early stages. WEHI-9625 preserves cellular function and long-term clonogenic potential before apoptosis induced mitochondrial damage. WEHI-9625 is inactive against both human BAK (hBAK) and BAX.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mark F van Delft et al.
Nature chemical biology, 15(11), 1057-1066 (2019-10-09)
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have been favored, but
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3837-10MG | 04065270396549 |