SML3842
TAT-SAMβA trifluoroacetate
≥95% (HPLC)
Synonym(s):
SAMβA trifluoroacetate, TAT(47-57)-GG-βIIPKC(624-632) trifluoroacetate, TAT(47-57)-GG-SAMβA trifluoroacetate, YGRKKRRQRRR-GG-RNAENFDRF trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C118H195N51O31 · xC2HF3O2
Molecular Weight:
2824.13 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1.
TAT-SAMβA is a mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1. TAT-SAMβA protects neonatal and adult rat cardiac myocytes, but not Mfn1-knockout cells, from stress-induced death in cultures and improves cardiac contractility in rats with heart failure in vivo (3 mg/kg/day for 6 wks via Alzet pump delivery) by re-establishing mitochondrial morphology and function. TAT-SAMβA is composed of a 9-aa βIIPKC-derived MFN1-interacting sequence linked at the N-terminal to the cell permeable TAT(47-57) via a -Gly-Gly- spacer
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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A selective inhibitor of mitofusin 1-?IIPKC association improves heart failure outcome in rats
Nature Communications, 10(1), 329-329 (2019)
The Mfn1-?IIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage
Translational Stroke Research, 13(5), 845-857 (2022)
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