SML3845
Enterocin
≥95% (HPLC)
Synonym(s):
(3R,4aR,5S,6S,7S,7aS,8R)-7-Benzoylhexahydro-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-3,6-methanocyclopenta[c]pyran-1(3H)-one, Vulgamycin
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About This Item
Empirical Formula (Hill Notation):
C22H20O10
CAS Number:
Molecular Weight:
444.39
NACRES:
NA.21
UNSPSC Code:
51111800
assay
≥95% (HPLC)
form
(Powder or lyophilized powder)
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Broad-spectrum antibiotic with activity against both gram-positive and gram-negative bacteria
Enterocin is a bacteriostatic polyketide antibiotic unrelated to the polypeptide enterocin bacteriocins. It has broad-spectrum antibiotic activity against both gram-positive and gram-negative bacteria. Enterocin has also been shown to have inhibitory activity against β-amyloid protein (Aβ1-42) fibrillation and moderate cytotoxicity against HeLa and HepG2 cancer cell lines.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Exploring Natural Product Artifacts: The Polyketide Enterocin Warms to a Ballet of Isomers
Organic Letters, 22(12), 4828-4832 (2020)
Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin
Journal of Natural Products, 78(3), 539-542 (2015)
Dong-Bo Xu et al.
Applied microbiology and biotechnology, 99(14), 5825-5832 (2015-04-22)
The type II polyketide synthase (PKS) natural product enterocin (1) was isolated from a mangrove-derived novel species Streptomyces qinglanensis 172205 guided by genome sequence, and its putative biosynthetic gene cluster was revealed. Its natural analogues 5-deoxyenterocin (2) and wailupemycin A-C
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