Skip to Content
Merck
CN

SML3846

Sigma-Aldrich

Motixafortide trifluoroacetate

≥95% (HPLC)

Synonym(s):

TF 14016 trifluoroacetate, B 4F-benzoyl-TN14003 trifluoroacetate, BKT 140 trifluoroacetate, BKT140 trifluoroacetate, N2-(4-Fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl- L-argininamide cyclic (4→13)-disulfide trifluoroacetate, TF14016 trifluoroacetate

Sign Into View Organizational & Contract Pricing

Select a Size


About This Item

Empirical Formula (Hill Notation):
C97H144FN33O19S2 · xC2HF3O2
Molecular Weight:
2159.52 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.21
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

SMILES string

O=C(NCCCC1NC(C(CCCNC(N)=N)NC(C(CC2=CC=C(C=C2)O)NC(C3N(CCC3)C(C(CCCCN)NC(C(CCCCN)NC(C(CCCNC(N)=O)NC(C(CC4=CC=C(C=C4)O)NC(C(CSSCC(C(NC(CCCNC(N)=N)C(N)=O)=O)NC1=O)NC(C(CC5=CC6=C(C=CC=C6)C=C5)NC(C(CCCNC(N)=N)NC(C(CCCNC(N)=N)NC(C7=CC=C(C=C7)F)=O)=O)=O)=O)=O)=O

Biochem/physiol Actions

Motixafortide (BKT140, BL-8040) is an orally available, highly selective inverse agonist of CXCR4 (CXC Chemokine Receptor 4). Motixafortide is a potent stem cell mobiliser and anticancer agent. BKT140 potently inhibits CXCL12 induced migration/invasion of small-cell lung cancer cells.
Orally available, highly selective inverse agonist of CXCR4

Disclaimer

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Targeting the CD20 and CXCR4 pathways in non-hodgkin lymphoma with rituximab and high-affinity CXCR4 antagonist BKT140
Clinical Cancer Research, 19(13), 3495-3507 (2013)
The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression
Leukemia, 31(11), 2336-2346 (2017)
Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4F-benzoyl-TN14003
Stem Cells, 25(9), 2158-2166 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service