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About This Item
Empirical Formula (Hill Notation):
C13H13N3O6S
CAS Number:
Molecular Weight:
339.32
MDL number:
NACRES:
NA.21
assay
≥98% (HPLC)
form
powder
color
, Light yellow to light orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Broad-spectrum first generation cephalosporin antibiotic against gram-positive and gram-negative bacteria.
Cefacetrile (cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic against gram-positive and gram-negative bacteria. Cefacetrile inhibits the third and last stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Cefacetrile (cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic against gram-positive and gram-negative bacteria. Cefacetrile inhibits the third and last stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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P Bianchi et al.
Bollettino dell'Istituto sieroterapico milanese, 58(6), 488-495 (1980-01-31)
6-cephalosporins (cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime, cefotaxime) has been tested in vitro against 212 gram negative bacteria and 60 Staphylococci. Cefuroxime and especially Cefotaxime showed the highest activity against the gram negative bacteria, with a very low MIC. Cefotaxime also
M G Bals et al.
Infection, 3(3), 161-164 (1975-01-01)
Cephacetrile, a parenteral cephalosporin, was evaluated for in vitro antibacterial activity, clinical pharmacology and effectiveness in the treatment of severe infections. The antibacterial activity against 187 isolates was determined by an agar-dilution technique. The MICs were 0.06 to 0.5 mug/ml
Comparative evaluation of cephacetrile in experimentally induced bovine mastitis.
J Schluep et al.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 26(4), 304-324 (1979-05-01)
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