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Merck
CN

SML3859

Cefacetrile

≥98% (HPLC)

Synonym(s):

(6R,7R)-3-(Acetoxymethyl)-7-(cyanoacetamido)-8-oxo-5-thia-1azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-Cyanoacetamidocephalosporanic acid, Cephacetrile

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About This Item

Empirical Formula (Hill Notation):
C13H13N3O6S
CAS Number:
Molecular Weight:
339.32
MDL number:
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

, Light yellow to light orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Broad-spectrum first generation cephalosporin antibiotic against gram-positive and gram-negative bacteria.
Cefacetrile (cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic against gram-positive and gram-negative bacteria. Cefacetrile inhibits the third and last stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Comparative evaluation of cephacetrile in experimentally induced bovine mastitis.
J Schluep et al.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 26(4), 304-324 (1979-05-01)
M G Bals et al.
Infection, 3(3), 161-164 (1975-01-01)
Cephacetrile, a parenteral cephalosporin, was evaluated for in vitro antibacterial activity, clinical pharmacology and effectiveness in the treatment of severe infections. The antibacterial activity against 187 isolates was determined by an agar-dilution technique. The MICs were 0.06 to 0.5 mug/ml
P Bianchi et al.
Bollettino dell'Istituto sieroterapico milanese, 58(6), 488-495 (1980-01-31)
6-cephalosporins (cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime, cefotaxime) has been tested in vitro against 212 gram negative bacteria and 60 Staphylococci. Cefuroxime and especially Cefotaxime showed the highest activity against the gram negative bacteria, with a very low MIC. Cefotaxime also

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