SML3863
Tecovirimat
≥98% (HPLC)
Synonym(s):
4-Trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide, SIGA-246, ST-246, rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide
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About This Item
Empirical Formula (Hill Notation):
C19H15F3N2O3
CAS Number:
Molecular Weight:
376.33
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Antiviral with activity against orthopoxviruses such as cowpox and monkeypox and including smallpox
Tecovirimat (ST-246) is an antiviral with activity against orthopoxviruses such as cowpox and monkeypox and including smallpox. Tecovirimat inhibits the function of a major envelope protein required for the production of extracellar virus, prevented the virus from leaving the cell, and spreading within the body. FDA-approved for the treatment of human smallpox disease caused by Variola virus in adults and children.
Disclaimer
Research use only, not for use in humans.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox)
Antimicrobial Agents and Chemotherapy, 57(12), 6246-6253 (2013)
Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals
PLoS ONE, 8(2), e55808-e55808 (2013)
Fragment-Based Approaches Identified Tecovirimat-Competitive Novel Drug Candidate for Targeting the F13 Protein of the Monkeypox Virus
Viruses, 15(2), 570-570 (2023)
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