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Merck
CN

SML3869

Avibactam Sodium

≥98% (HPLC), β-lactamase inhibitor, powder

Synonym(s):

(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt, AVE1330A sodium salt, NXL-104 sodium salt, Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester sodium salt

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About This Item

Empirical Formula (Hill Notation):
C7H10N3NaO6S
CAS Number:
1192491-61-4
Molecular Weight:
287.23
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
MFCD28900719

Key Documents

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Product Name

Avibactam Sodium, ≥98% (HPLC)

SMILES string

[Na+].[S](=O)(=O)([O-])ON1[C@H]2CN([C@@H](CC2)C(=O)N)C1=O

InChI key

RTCIKUMODPANKX-JBUOLDKXSA-M

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Avibactam is a reversible non-β-lactam β-lactamase inhibitor with IC50 values of 5 nM for CTX-M-15, 8nM for TEM-1, and 80 nM for P99 β-lactamase enzymes.
Reversible non-β-lactam, β-lactamase inhibitor

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000497641
0000497641
0000489456
0000489457
0000489457

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Efficacies of ceftazidime-avibactam and ceftazidime against Pseudomonas aeruginosa in a murine lung infection model
Antimicrobial Agents and Chemotherapy, 58(3), 1365-1371 (2014)
Carbapenemase Inhibitors: Updates on Developments in 2021
Journal of clinical medicine research, 14(7), 251-259 (2022)
Avibactam is a covalent, reversible, non-?-lactam ?-lactamase inhibitor
Proceedings of the National Academy of Sciences of the USA, 109(29), 11663-11668 (2012)

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