SML3876
SHM115
≥98% (HPLC)
Synonym(s):
6-((Perfluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyridin-5-ol, 6-[(2,3,4,5,6-Pentafluorophenyl)amino]-[1,2,5]oxadiazolo[3,4-b]pyridin-5(3H)-one
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=NC2=NON=C2C=C1NC3=C(C(F)=C(C(F)=C3F)F)F
Biochem/physiol Actions
Orally active mitochondria uncoupler that increases the energy expenditure and lowers the body fat mass in vivo.
SHM115 is an orally active mitochondria uncoupler (EC50 = 17 μM; measured as oxygen consumption rate (OCR) increase in L6 rat myoblast cells) that increases the energy expenditure and lowers the body fat mass in two diet-induced obesity mouse models, including an obesity prevention model (130 mg/kg/d via chow) and an obesity reversal model (130 mg/kg/d via oral gavage).
SHM115 is an orally active mitochondria uncoupler (EC50 = 17 μM; measured as oxygen consumption rate (OCR) increase in L6 rat myoblast cells) that increases the energy expenditure and lowers the body fat mass in two diet-induced obesity mouse models, including an obesity prevention model (130 mg/kg/d via chow) and an obesity reversal model (130 mg/kg/d via oral gavage).
Regulatory Information
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