SML3877
SRI-32743
≥98% (HPLC)
Synonym(s):
2-(7-Methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenylbutyl)-4-quinazolinamine
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About This Item
Empirical Formula (Hill Notation):
C26H25N5
CAS Number:
Molecular Weight:
407.51
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake.
SRI-32743 is an allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake. SRI-32743 attenuates Tat (the HIV regulatory protein transactivator of transcription) induced inhibition of DAT-mediated dopamine uptake. Also, it alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
SRI-32743 is an allosteric modulator of monoamine transporters that acts as partial antagonists of dopamine uptake. SRI-32743 attenuates Tat (the HIV regulatory protein transactivator of transcription) induced inhibition of DAT-mediated dopamine uptake. Also, it alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice
Journal of Pharmacology and Experimental Therapeutics, 384(2), 306-314 (2023)
SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice
Neuropharmacology, 220, 109239-109239 (2022)
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