SML3888
Dynapyrazole Compound 20
≥98% (HPLC)
Synonym(s):
6-(3-bromophenoxy)-2- [1-(4-chlorophenyl) cyclopropyl]-7-oxo-4H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Compound 20
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About This Item
Empirical Formula (Hill Notation):
C22H14BrClN4O2
Molecular Weight:
481.73
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Dynapyrazole Compound 20 is a potent and selective inhibitor of cytoplasmic S. cerevisiae dynein, an AAA (ATPase associated with diverse cellular activities), which engages the regulatory ATPase sites in the AAA3 and AAA4 domains disrupting allosteric communication across the AAA ring. Ddynapyrazole Compound 20 inhibits dynein’s basal ATPase activity. Also, it inhibits dynein motility by reducing the protein’s ability to bind microtubules.
Potent and selective inhibitor of cytoplasmic S. cerevisiae dynein
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cristina C Santarossa et al.
Cell chemical biology, 28(10), 1460-1473 (2021-05-21)
Cytoplasmic dyneins are AAA (ATPase associated with diverse cellular activities) motor proteins responsible for microtubule minus-end-directed intracellular transport. Dynein's unusually large size, four distinct nucleotide-binding sites, and conformational dynamics pose challenges for the design of potent and selective chemical inhibitors.
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