SML3888
Dynapyrazole Compound 20
≥98% (HPLC)
别名:
6-(3-bromophenoxy)-2- [1-(4-chlorophenyl) cyclopropyl]-7-oxo-4H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Compound 20
相关类别
生化/生理作用
Dynapyrazole Compound 20 is a potent and selective inhibitor of cytoplasmic S. cerevisiae dynein, an AAA (ATPase associated with diverse cellular activities), which engages the regulatory ATPase sites in the AAA3 and AAA4 domains disrupting allosteric communication across the AAA ring. Ddynapyrazole Compound 20 inhibits dynein’s basal ATPase activity. Also, it inhibits dynein motility by reducing the protein’s ability to bind microtubules.
Potent and selective inhibitor of cytoplasmic S. cerevisiae dynein
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Cristina C Santarossa et al.
Cell chemical biology, 28(10), 1460-1473 (2021-05-21)
Cytoplasmic dyneins are AAA (ATPase associated with diverse cellular activities) motor proteins responsible for microtubule minus-end-directed intracellular transport. Dynein's unusually large size, four distinct nucleotide-binding sites, and conformational dynamics pose challenges for the design of potent and selective chemical inhibitors.
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