SML3899
L-371,257
≥98% (HPLC)
Synonym(s):
1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)-piperidine, L 371257
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About This Item
Empirical Formula (Hill Notation):
C28H33N3O6
CAS Number:
Molecular Weight:
507.58
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Product Name
L-371,257, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Highly potent and selective oxytocin receptor antagonist
L-371,257 is a highly potent and selective antagonist of human oxytocin receptor. L-371,257 potently inhibits oxytocin-induced contractions of the rat uterus in vitro and in vivo. L-371,257 exhibits good oral availability in rats. It exhibits good peripheral selectivity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist
Journal of medicinal chemistry, 38(23), 4634-4636 (1995)
Relevance of number and physiological status of conspecifics in preventing stress-induced decreases in newly proliferated cells and neuroblasts
Psychopharmacology, 236(11), 3329-3339 (2019)
A Tahara et al.
British journal of pharmacology, 129(1), 131-139 (2000-02-29)
[(3)H]-oxytocin was used to characterize the oxytocin receptor found in human uterine smooth muscle cells (USMC). Specific binding of [(3)H]-oxytocin to USMC plasma membranes was dependent upon time, temperature and membrane protein concentration. Scatchard plot analysis of equilibrium binding data
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