SML3900
955, CDK9 PROTAC trifluoroacetate
≥98% (HPLC)
Synonym(s):
(E)-N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide trifluoroacetate, PL-SNS-032 conjugate 955 trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C41H53N7O8S2 · xC2HF3O2
Molecular Weight:
836.03 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
955 CDK9 PROTAC is a cell penetrant conjugate of the CDK9 inhibitor SNS-032 with new recruiter of the E3 ligase KEAP1 piperlongumine that potently degrades CDK9 in MOLT4 cells. Similarly, to THAL-SNS-032, 955 induces CDK10 degradation. 955 exhibits potent antiproliferative activity in several prostate cancer cell lines including LNCaP, 22RV1, PC3 and DU145 cells.
Cell penetrant, potent and selective CDK9 degrader
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Piperlongumine conjugates induce targeted protein degradation
Cell Chemical Biology, 30(2) (2023)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3900-25MG | 04065270748904 |
| SML3900-5MG | 04065270749413 |