SML3927
Alalevonadifloxacin hydrochloride
≥98% (HPLC)
Synonym(s):
L-Alanine 1-[(5S)-2-carboxy-9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizin-8-yl]-4-piperidinyl ester hydrochloride, WCK 2349 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C22H26FN3O5·HCl
CAS Number:
Molecular Weight:
467.92
NACRES:
NA.77
UNSPSC Code:
51111800
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Orally available L-alanine ester prodrug of Levonadifloxacin that is affective against Gram-positive and Gram-negative bacteria.
Alalevonadifloxacin, the L-alanine ester prodrug of levonadifloxacin, is an orally available and potent benzoquinolizine fluoroquinolone antibiotic that is affective against Gram-positive and Gram-negative bacteria, including methicillin- and quinolone-resistant Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis and atypical pathogens. Alalevonadifloxacin targets staphylococcal DNA gyrase, unlike other quinolones, which primarily inhibit DNA topoisomerase IV.
Alalevonadifloxacin, the L-alanine ester prodrug of levonadifloxacin, is an orally available and potent benzoquinolizine fluoroquinolone antibiotic that is affective against Gram-positive and Gram-negative bacteria, including methicillin- and quinolone-resistant Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis and atypical pathogens. Alalevonadifloxacin targets staphylococcal DNA gyrase, unlike other quinolones, which primarily inhibit DNA topoisomerase IV.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
Drug design, development and therapy, 13, 4351-4365 (2019)
Design and synthesis of an oral prodrug alalevonadifloxacin for the treatment of MRSA infection
Bioorganic & Medicinal Chemistry Letters, 54, 128432-128432 (2021)
Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects
Keith A Rodvold, Mark H Gotfried
Antimicrobial Agents and Chemotherapy, 62(3) (2018)
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