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Merck
CN

SML3934

JA397

≥98% (HPLC)

Synonym(s):

tert-butyl 3-((2-((4-((tert-butoxycarbonyl)amino)benzyl)amino)pyrimidin-4-yl)amino)-1H-pyrazole-5-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C24H31N7O4
Molecular Weight:
481.55
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell penetrant, potent and selective inhibitor CDK14-18 (TAIRE family).
JA397 is a cell penetrant, potent and selective inhibitor for the TAIRE family of the cyclin-dependent kinases (CDK14-18).

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000476160
0000476157
0000476157
0000476160

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Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family
Amrhein JA, et al.
International Journal of Molecular Sciences, 23 (2022)

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