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About This Item
Empirical Formula (Hill Notation):
C26H25N3O5
CAS Number:
Molecular Weight:
459.49
NACRES:
NA.21
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
CC1=NC2=C(C(N1C3=CC=C(NC(CC4=CC(OC)=C(OC)C(OC)=C4)=O)C=C3)=O)C=CC=C2
Related Categories
Biochem/physiol Actions
Selective and efficacious in vivo inhibitor of ferroptosis-suppressor-protein 1 (FSP1); ferroptosis inducer.
icFSP1 is a selective and efficacious in vivo inhibitor of ferroptosis-suppressor-protein 1 (FSP1). icFSP1 triggers subcellular relocalization of FSP1 from the membrane and initiate FSP1 reversible aggregation into liquid droplet-like structures before ferroptosis initiation. It synergizes with ferroptosis inducing agents to potentiate the ferroptotic cell death response.
icFSP1 is a selective and efficacious in vivo inhibitor of ferroptosis-suppressor-protein 1 (FSP1). icFSP1 triggers subcellular relocalization of FSP1 from the membrane and initiate FSP1 reversible aggregation into liquid droplet-like structures before ferroptosis initiation. It synergizes with ferroptosis inducing agents to potentiate the ferroptotic cell death response.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Toshitaka Nakamura et al.
Nature, 619(7969), 371-377 (2023-06-29)
Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour entities including therapy-refractory and dedifferentiating cancers1-3. Recently, ferroptosis suppressor protein-1 (FSP1), along with extramitochondrial ubiquinone or exogenous vitamin K and NAD(P)H/H+ as an electron donor, has been identified
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