SML3937
GPX4-Activator-1d4 Hydrochloride
≥98% (HPLC)
Synonym(s):
N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)-benzenesulfonamide hydrochloride, N-(2-Aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide hydrochloride, PKUMDL-LC-101-D04
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About This Item
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl
InChI key
FELDRJSFLBINQS-UHFFFAOYSA-N
Biochem/physiol Actions
GPX4-Activator-1d4 HCl is a cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis. It significantly increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. GPX4-Activator-1d4 suppresses ferroptosis and inflammation in HT-1080 fibrosarcoma cells.
Disclaimer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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