SML3937
GPX4-Activator-1d4 Hydrochloride
≥98% (HPLC)
Synonym(s):
N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)-benzenesulfonamide hydrochloride, N-(2-Aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide hydrochloride, PKUMDL-LC-101-D04
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About This Item
Empirical Formula (Hill Notation):
C14H22N4O2S2·HCl
CAS Number:
Molecular Weight:
378.94
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl
InChI key
FELDRJSFLBINQS-UHFFFAOYSA-N
Biochem/physiol Actions
Cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis.
GPX4-Activator-1d4 HCl is a cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis. It significantly increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. GPX4-Activator-1d4 suppresses ferroptosis and inflammation in HT-1080 fibrosarcoma cells.
GPX4-Activator-1d4 HCl is a cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis. It significantly increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. GPX4-Activator-1d4 suppresses ferroptosis and inflammation in HT-1080 fibrosarcoma cells.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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