SML3938
H55
≥98% (HPLC)
Synonym(s):
(Z)-4-(4-(4-bromophenyl)-2-(phenylimino)thiazol-3(2H)-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one, Erg6 inhibitor H55
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About This Item
Empirical Formula (Hill Notation):
C26H21BrN4OS
CAS Number:
Molecular Weight:
517.44
NACRES:
NA.77
UNSPSC Code:
51111800
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent and selective allosteric inhibitor of the fungal-specific enzyme Erg6 that induces accumulation of zymosterol and farnesol in pathogenic fungus C. albicans.
H55 is a cell penetrant, potent and selective allosteric inhibitor of the fungal-specific enzyme Erg6 (C-24 sterol methyltransferase) that induces accumulation of zymosterol and farnesol in pathogenic fungus Candida albicans. H55 potently inhibits C. albicans hyphal formation. Treatment of mice infected with C. albicans with H55 alleviates the severity of the infection and improves the survival.
H55 is a cell penetrant, potent and selective allosteric inhibitor of the fungal-specific enzyme Erg6 (C-24 sterol methyltransferase) that induces accumulation of zymosterol and farnesol in pathogenic fungus Candida albicans. H55 potently inhibits C. albicans hyphal formation. Treatment of mice infected with C. albicans with H55 alleviates the severity of the infection and improves the survival.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections
Cell Chemical Biology, 30(5) (2023)
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