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About This Item
Empirical Formula (Hill Notation):
C17H16N2OHCl
CAS Number:
Molecular Weight:
300.78
NACRES:
NA.21
SMILES string
C=CC[C@H](N)C(C=CC=C1)=C1C2=NOC3=CC=CC=C32.Cl
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity.
Org 34167 is a brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity in human and rat models. Apparently, Org 34167 inhibits HCN1 channel activity by modulating hyperpolarizing shift in activation voltage dependence and a slowing of activation kinetics.
Org 34167 is a brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity in human and rat models. Apparently, Org 34167 inhibits HCN1 channel activity by modulating hyperpolarizing shift in activation voltage dependence and a slowing of activation kinetics.
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