SML3945
ARN11391
≥98% (HPLC)
Synonym(s):
2-Ethyl-N-[2-(oxan-2-ylmethoxy)phenyl]-4,5,6,7-tetrahydroindazole-3-carboxamide, ARN 11391, ARN-11391
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About This Item
Empirical Formula (Hill Notation):
C22H29N3O3
CAS Number:
Molecular Weight:
383.48
NACRES:
NA.77
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Selective inositol triphosphate receptor type 1 (ITPR1) potentiator for wild-type as well as two ITPR1 SCA29 mutants, R269W or T267M.
ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 µM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) that potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 µM UTP with or without 10 µM ARN11391).
ARN11391 is a selective inositol triphosphate receptor type 1 (ITPR1), but not ITPR2 or ITPR3, potentiator (open channel probability (Po) = 0.2 with 20 µM ARN11391 and <0.01 without by on-nucleus nuclear patch-clamp using TPR1-YFP-expressing HEK293 cells) that potenitates IP3- (by photolysis of caged IP3) and UPT-induced calcium increase in HEK293 transfectants expressing wild-type as well as ITPR1 SCA29 mutants, R269W or T267M (5 µM UTP with or without 10 µM ARN11391).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Michele Genovese et al.
PNAS nexus, 2(1), pgac288-pgac288 (2023-01-31)
Pharmacological modulators of the Ca2+ signaling cascade are important research tools and may translate into novel therapeutic strategies for a series of human diseases. We carried out a screening of a maximally diverse chemical library using the Ca2+-sensitive Cl- channel
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3945-25MG | 04065271155190 |
| SML3945-5MG | 04065271156807 |
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