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Merck
CN

SML3956

Cdk5i SC-FT trifluoroacetate

≥95% (HPLC)

Synonym(s):

Cdk5i-FT negative control trifluoroacetate, Cdk5i-FT scrambled control trifluoroacetate, FITC-Ahx-AFRSPCARIGYV-TAT trifluoroacetate, FITC-Ahx-AFRSPCARIGYV-YGRKKRRQRRR (FITC = fluorescein isothiocyanate; Ahx = 6-aminohexanoate) trifluoroacetate, FITC-Ahx-Cdk5i SC-TAT trifluoroacetate, SC-FT trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C151H232N52O34S2
Molecular Weight:
3383.92
UNSPSC Code:
12352200
NACRES:
NA.21

Key Documents

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assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to beige

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Scrambled control for the brain-penetrant and selective cyclin-dependent kinase Cdk5/p25 complex inhibitor Cdk5i-FT.

Cdk5i SC-FT is the scrambled control for Cdk5i-FT, a brain-penetrant and selective cyclin-dependent kinase Cdk5/p25 complex inhibitor in vitro and in vivo.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Ping-Chieh Pao et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(16), e2217864120-e2217864120 (2023-04-13)
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity.

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