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SML3960

JNJ-42226314

≥98% (HPLC)

Synonym(s):

[1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, [4-[1-[[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolylmethanone

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About This Item

Empirical Formula (Hill Notation):
C26H24FN5O2S
CAS Number:
1252765-13-1
Molecular Weight:
489.56
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32671350
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL).


JNJ-42226314 is a brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL)(IC50 = 1.1) that exhibits antinociceptive efficacy in the rat models neuropathic and inflammatory pain. JNJ-42226314 elevates hippocampal 2-arachidonoylglycerol (2-AG) levels and prolongs wakefulness in rats.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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