SML3963
DPPA-1 acetate
≥95% (HPLC)
Synonym(s):
(D)-APP acetate, (D)-NYSKPTDRQYHF acetate, (D)-PPA 1 acetate, (D)-PPA acetate, (D)-PPA-1 acetate, (D)-PPA1 acetate, Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe (all D-amino acids) acetate, D PD-1/PD-L1 interaction Antagonist-1 acetate, D-APP acetate, D-Asn-D-Tyr-D-Ser-D-Lys-D-Pro-D-Thr-D-Asp-D-Arg-D-Gln-D-Tyr-D-His-D-Phe, D-PPA 1 acetate, D-PPA acetate, D-type APP acetate, D-type anti-PD-L1 peptide acetate, DPPA 1 acetate, DPPA-1 acetate, DPPA1 acetate, NYSKPTDRQYHF (all D-amino acids) acetate, PD-L1-targeting D-peptide acetate
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About This Item
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
DPPA-1 is a programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1) interaction antagonist/blocker that targets PD-L1 via direct affinity binding (KD = 0.51 μM). DPPA-1 effectively blocks soluble Fc-labeled human PD-L1 from binding cell surface PD-1 in vitro and shows anti-tumor efficacy among CT26 tumor-bearing mice in vivo (2 mg/kg via daily i.p.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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