Skip to Content
Merck
CN

SML3968

NSI-189

≥98% (HPLC)

Synonym(s):

(4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone, NSI 189, [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C22H30N4O
CAS Number:
1270138-40-3
Molecular Weight:
366.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD26959792
Form:
powder
Assay:
≥98% (HPLC)
Solubility:
DMSO: 2 mg/mL, clear
Color:
white to beige

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

N2(CCN(CC2)C(=O)c3c(nccc3)NCCC(C)C)Cc1ccccc1

InChI

1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)

InChI key

DYTOQURYRYYNOR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Orally available neurogenic drug that ameliorates impaired memory function in Zucker diabetic fatty rats; exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities.


NSI-189 is an orally available neurogenic drug with pleiotropic properties that ameliorates impaired memory function and plasticity in Zucker diabetic fatty rat model of type 2 diabetes through enhanced expression of mitochondrial complexes I, III, IV, and V. NSI-189 exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities in patients with major depressive disorder.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000339070
0000339071
0000323672
0000323672
0000339071

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189
Diabetes, 68(11), 2143-2154 (2019)
Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes
Journal of Diabetes Research, 2022, 8566970-8566970 (2022)
A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients
Molecular Psychiatry, 21(10), 1372-1380 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service