SML3968
NSI-189
≥98% (HPLC)
Synonym(s):
(4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone, NSI 189, [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone
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About This Item
Empirical Formula (Hill Notation):
C22H30N4O
CAS Number:
Molecular Weight:
366.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Form:
powder
Assay:
≥98% (HPLC)
Solubility:
DMSO: 2 mg/mL, clear
Color:
white to beige
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
N2(CCN(CC2)C(=O)c3c(nccc3)NCCC(C)C)Cc1ccccc1
InChI
1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
InChI key
DYTOQURYRYYNOR-UHFFFAOYSA-N
Biochem/physiol Actions
Orally available neurogenic drug that ameliorates impaired memory function in Zucker diabetic fatty rats; exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities.
NSI-189 is an orally available neurogenic drug with pleiotropic properties that ameliorates impaired memory function and plasticity in Zucker diabetic fatty rat model of type 2 diabetes through enhanced expression of mitochondrial complexes I, III, IV, and V. NSI-189 exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities in patients with major depressive disorder.
NSI-189 is an orally available neurogenic drug with pleiotropic properties that ameliorates impaired memory function and plasticity in Zucker diabetic fatty rat model of type 2 diabetes through enhanced expression of mitochondrial complexes I, III, IV, and V. NSI-189 exhibits long-acting antidepressant, procognitive, synaptoplastic, and neurotrophic activities in patients with major depressive disorder.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189
Diabetes, 68(11), 2143-2154 (2019)
Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes
Journal of Diabetes Research, 2022, 8566970-8566970 (2022)
A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients
Molecular Psychiatry, 21(10), 1372-1380 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3968-25MG | 04065271056749 |
| SML3968-5MG | 04065271056756 |