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Merck
CN

SML3979

R-(-)-Ketamine hydrochloride

≥95% (HPLC)

Synonym(s):

(-)-Ketamine hydrochloride, Arketamine hydrochloride, (R)-Ketamine hydrochloride, (2R)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (1:1)

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About This Item

Empirical Formula (Hill Notation):
C13H16ClNO· HCl
CAS Number:
Molecular Weight:
274.19
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥95% (HPLC)

form

powder

drug control

USDEA Schedule III

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

(R)-Ketamine (Arketamine), whose metabolite (2R,6R)-hydroxynorketamine exhibits AMPAR-modulating activity, contributes mainly to ketamine′s antidepressant efficacy. (S)-ketamine (Esketamine), on the other hand, is an NMDAR phencyclidine (PCP)-site antagonist that contributes to ketamine′s analgesic efficacy. Studies in rats and mice show that (R)-Ketamine displays the highest antidepressant potency and the least side-effects when compared with the racemate and (S)-ketamine.

Disclaimer

Hygroscopic Store with desiccant


pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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