SML3984
Insulin sensitizer, C59
≥98% (HPLC)
Synonym(s):
N-(4,5-Dichloro-2-pyridinyl)tricyclo[3.3.1.13,7]decane-1-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C16H18Cl2N2O
CAS Number:
Molecular Weight:
325.23
NACRES:
NA.21
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice; restores insulin-stimulated GLUT4 translocation.
Insulin sensitizer C59 is an orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice. Insulin sensitizer C59 restores insulin-stimulated GLUT4 translocation without targeting PPARγ. It acts through interaction with Unc119 proteins. C59 lowers fasting blood glucose and plasma insulin concentrations in in DIO mice.
Insulin sensitizer C59 is an orally available potentiator of insulin action that significantly improves glucose tolerance in DIO mice. Insulin sensitizer C59 restores insulin-stimulated GLUT4 translocation without targeting PPARγ. It acts through interaction with Unc119 proteins. C59 lowers fasting blood glucose and plasma insulin concentrations in in DIO mice.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Terry C Yin et al.
Cell chemical biology, 30(8), 933-942 (2023-07-16)
Insulin resistance (IR) is the root cause of type II diabetes, yet no safe treatment is available to address it. Using a high throughput compatible assay that measures real-time translocation of the glucose transporter glucose transporter 4 (GLUT4), we identified
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