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Merck
CN

SML3996

Sigma-Aldrich

Pentachloropseudilin

≥98% (HPLC)

Synonym(s):

2,4-Dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol, 2,4-Dichloro-6-(3,4,5-trichloro-2-pyrrolyl)phenol, Antibiotic A 15104Y, PClP

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About This Item

Empirical Formula (Hill Notation):
C10H4Cl5NO
CAS Number:
69640-38-6
Molecular Weight:
331.41
MDL number:
MFCD25966287

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

OC1=C(C2=C(Cl)C(Cl)=C(Cl)N2)C=C(Cl)C=C1Cl

InChI

1S/C10H4Cl5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H

InChI key

FBRLLYYPGGXCKT-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin; inhibits T. cruzi parasite motility.
Pentachloropseudilin is a reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin. Pentachloropseudilin is a natural product present in marine bacteria Chromobacterium sp., Pseudomonas bromoutilis, and Alteromonas luteoviolaceus. Pentachloropseudilin inhibits T. cruzi parasite motility, host cell adhesion and invasion.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000385464
0000385461
0000373477
0000385464
0000385461

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Krishna Chinthalapudi et al.
The Journal of biological chemistry, 286(34), 29700-29708 (2011-06-18)
Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than
Mylla Spirandelli da Costa et al.
Chembiochem : a European journal of chemical biology, 23(18), e202200349-e202200349 (2022-07-16)
Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not
Myosin 1c: A novel regulator of glucose uptake in brown adipocytes
Molecular Metabolism (2021)

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