SML3996
Pentachloropseudilin
≥98% (HPLC)
Synonym(s):
2,4-Dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol, 2,4-Dichloro-6-(3,4,5-trichloro-2-pyrrolyl)phenol, Antibiotic A 15104Y, PClP
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About This Item
Empirical Formula (Hill Notation):
C10H4Cl5NO
CAS Number:
Molecular Weight:
331.41
MDL number:
NACRES:
NA.21
InChI
1S/C10H4Cl5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H
InChI key
FBRLLYYPGGXCKT-UHFFFAOYSA-N
SMILES string
OC1=C(C2=C(Cl)C(Cl)=C(Cl)N2)C=C(Cl)C=C1Cl
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin; inhibits T. cruzi parasite motility.
Pentachloropseudilin is a reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin. Pentachloropseudilin is a natural product present in marine bacteria Chromobacterium sp., Pseudomonas bromoutilis, and Alteromonas luteoviolaceus. Pentachloropseudilin inhibits T. cruzi parasite motility, host cell adhesion and invasion.
Pentachloropseudilin is a reversible allosteric inhibitor of myosin ATPase and motor activity specific for class-1 myosin. Pentachloropseudilin is a natural product present in marine bacteria Chromobacterium sp., Pseudomonas bromoutilis, and Alteromonas luteoviolaceus. Pentachloropseudilin inhibits T. cruzi parasite motility, host cell adhesion and invasion.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Myosin 1c: A novel regulator of glucose uptake in brown adipocytes
Molecular Metabolism (2021)
Mylla Spirandelli da Costa et al.
Chembiochem : a European journal of chemical biology, 23(18), e202200349-e202200349 (2022-07-16)
Pentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not
Krishna Chinthalapudi et al.
The Journal of biological chemistry, 286(34), 29700-29708 (2011-06-18)
Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than
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