SML3997
FOY-251 mesylate
≥98% (HPLC)
Synonym(s):
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, methanesulfonate; 4-(4-Guanidinobenzoyloxy)phenylacetic acid, methanesulfonate, CC6 mesylate salt, Camostat active metabolite, FOY 251 mesylate salt, FOY 305 active metabolite, FOY-305 active metabolite, FOY251 mesylate salt, GBPA mesylate salt
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About This Item
Empirical Formula (Hill Notation):
C16H15N3O4·CH4O3S
CAS Number:
Molecular Weight:
409.41
UNSPSC Code:
51111800
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O
InChI key
JXMOPIDYHUYOED-UHFFFAOYSA-N
Biochem/physiol Actions
Trypsin-like serine protease inhibitor Camostat (FOY-305) active metabolite with inhibitory potency against transmembrane serine protease 2 (TMPRSS2).
FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) that primes SARS-CoV-2 spike protein for host cell entry.
FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) that primes SARS-CoV-2 spike protein for host cell entry.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
Communications biology, 5(1), 681-681 (2022)
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
EBioMedicine, 65, 103255-103255 (2021)
New orally active serine protease inhibitors
Journal of medicinal chemistry, 38(14), 2521-2523 (1995)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML3997-25MG | 04065271165977 |
| SML3997-5MG | 04065271165984 |