SMILES string
O=C(C1=CC=CO1)NC(NC2=CC=C3C(C=CC=C3)=C2)C(Cl)(Cl)Cl
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent blocker of all Orai channels indiscriminately with an IC50 value of 195 nM in blocking SOCE in primary T cells.
Pan-Orai inhibitor 5D is a potent blocker of all Orai channels indiscriminately with an IC50 value of 195 nM in blocking SOCE in primary T cells. pan-Orai inhibitor 5D potently inhibits effector T-cell function and IL-2 production.
Pan-Orai inhibitor 5D is a potent blocker of all Orai channels indiscriminately with an IC50 value of 195 nM in blocking SOCE in primary T cells. pan-Orai inhibitor 5D potently inhibits effector T-cell function and IL-2 production.
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