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Merck
CN

SML4008

Sigma-Aldrich

Zuclopenthixol

≥98% (HPLC)

Synonym(s):

(Z)-4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol, 4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol

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About This Item

Empirical Formula (Hill Notation):
C22H25ClN2OS
CAS Number:
Molecular Weight:
400.96
MDL number:
UNSPSC Code:
12352200
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

S1c2c(cc(cc2)Cl)\C(=C/CCN4CCN(CC4)CCO)\c3c1cccc3

InChI key

WFPIAZLQTJBIFN-DVZOWYKESA-N

Biochem/physiol Actions

Oral and potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors.



Zuclopenthixol, a typical antipsychotic, is an oral and potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors. Zuclopenthixol is approved in some countries for treatment of schizophrenia and other psychoses. Zuclopenthixol is a cis isomer of neuroleptic clopenthixol.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Elham Sardari et al.
Multiple sclerosis and related disorders, 73, 104622-104622 (2023-03-24)
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease affecting numerous people worldwide. While the relapsing subtypes of MS are to some extent treatable, the disease remains incurable leading to progressive disability. Limited efficacy of current small molecule drugs necessitates development
Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses
Cochrane database of systematic reviews (Online) null
Jianjun Li et al.
Journal of oncology, 2022, 5490461-5490461 (2022-01-25)
Esophagus cancer (ESCA) is the sixth most frequent cancer in males, with 5-year overall survival of 15%-25%. RNA modifications function critically in cancer progression, and m6A regulators are associated with ESCA prognosis. This study further revealed correlations between m6A and

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