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Merck
CN

SML4009

Sigma-Aldrich

Zuclopenthixol decanoate

≥98% (HPLC)

Synonym(s):

Decanoic acid 2-[4-[(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazinyl]ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C32H43ClN2O2S
CAS Number:
64053-00-5
Molecular Weight:
555.21
MDL number:
MFCD03792797
UNSPSC Code:
12352116

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

oil

color

, Colorless to light brown

storage temp.

-10 to -25°C

SMILES string

ClC(C=C1)=CC2=C1SC3=CC=CC=C3/C2=C/CCN4CCN(CCOC(CCCCCCCCC)=O)CC4

InChI

1S/C32H43ClN2O2S/c1-2-3-4-5-6-7-8-15-32(36)37-24-23-35-21-19-34(20-22-35)18-11-13-27-28-12-9-10-14-30(28)38-31-17-16-26(33)25-29(27)31/h9-10,12-14,16-17,25H,2-8,11,15,18-24H2,1H3/b27-13-

InChI key

QRUAPADZILXULG-WKIKZPBSSA-N

Biochem/physiol Actions

Long-lasting injectable formulation (depot form) of Zuclopenthixol; potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors.

Zuclopenthixol decanoate is a long-lasting injectable formulation (depot form) of Zuclopenthixol. Zuclopenthixol decanoate is a potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors. Zuclopenthixol decanoate is approved in some countries for treatment of schizophrenia and other psychoses and recommended for patients who are agitated or aggressive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Christoph U Correll et al.
CNS drugs, 35(1), 39-59 (2021-01-29)
The availability of long-acting injectable (LAI) antipsychotics for the treatment of schizophrenia provides clinicians with options that deliver continuous drug exposure and may improve adherence compared with daily oral antipsychotics. However, all LAI antipsychotics have unique formulations and pharmacokinetic characteristics
Matthew Cordiner et al.
Therapeutic advances in psychopharmacology, 6(2), 66-76 (2016-05-04)
Antipsychotic polypharmacy (APP) is common clinical practice. Theoretically, APP runs the risk of additional side effects, drug interactions, adherence and cost. A limited evidence base is emerging to support the effectiveness of APP in clinical practice. Our companion paper highlighted
Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses
Cochrane database of systematic reviews (Online), 1999(2) (2000)

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