SML4009
Zuclopenthixol decanoate
≥98% (HPLC)
别名:
Decanoic acid 2-[4-[(3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazinyl]ethyl ester
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关于此项目
经验公式（希尔记法）:
C32H43ClN2O2S
化学文摘社编号:
分子量:
555.21
UNSPSC Code:
12352116
MDL number:
NACRES:
NA.21
InChI
1S/C32H43ClN2O2S/c1-2-3-4-5-6-7-8-15-32(36)37-24-23-35-21-19-34(20-22-35)18-11-13-27-28-12-9-10-14-30(28)38-31-17-16-26(33)25-29(27)31/h9-10,12-14,16-17,25H,2-8,11,15,18-24H2,1H3/b27-13-
InChI key
QRUAPADZILXULG-WKIKZPBSSA-N
SMILES string
ClC(C=C1)=CC2=C1SC3=CC=CC=C3/C2=C/CCN4CCN(CCOC(CCCCCCCCC)=O)CC4
assay
≥98% (HPLC)
form
oil
color
, Colorless to light brown
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Long-lasting injectable formulation (depot form) of Zuclopenthixol; potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors.
Zuclopenthixol decanoate is a long-lasting injectable formulation (depot form) of Zuclopenthixol. Zuclopenthixol decanoate is a potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors. Zuclopenthixol decanoate is approved in some countries for treatment of schizophrenia and other psychoses and recommended for patients who are agitated or aggressive.
Zuclopenthixol decanoate is a long-lasting injectable formulation (depot form) of Zuclopenthixol. Zuclopenthixol decanoate is a potent antagonist of D1/D2 dopamine receptors, α1-adrenergic receptors and 5-HT2 receptors. Zuclopenthixol decanoate is approved in some countries for treatment of schizophrenia and other psychoses and recommended for patients who are agitated or aggressive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Christoph U Correll et al.
CNS drugs, 35(1), 39-59 (2021-01-29)
The availability of long-acting injectable (LAI) antipsychotics for the treatment of schizophrenia provides clinicians with options that deliver continuous drug exposure and may improve adherence compared with daily oral antipsychotics. However, all LAI antipsychotics have unique formulations and pharmacokinetic characteristics
Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses
Cochrane database of systematic reviews (Online), 1999(2) (2000)
Matthew Cordiner et al.
Therapeutic advances in psychopharmacology, 6(2), 66-76 (2016-05-04)
Antipsychotic polypharmacy (APP) is common clinical practice. Theoretically, APP runs the risk of additional side effects, drug interactions, adherence and cost. A limited evidence base is emerging to support the effectiveness of APP in clinical practice. Our companion paper highlighted
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