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Merck
CN

SML4019

Neuromedin U-23 (rat) trifluoroacetate

≥95% (HPLC)

Synonym(s):

L-Tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-α-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide trifluoroacetate, Neuromedin U trifluoroacetate, Phe-Lys-Ala-Glu-Tyr-Gln-Ser-Pro-Ser-Val-Gly-Gln-Ser-Lys-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 trifluoroacetate, Rat neuromedin U-23 trifluoroacetate, YKVNEYQGPVAPSGGFFLFRPRN-NH2 trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C124H180N34O31
Molecular Weight:
2642.97
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
100
Storage condition:
desiccated

Key Documents

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SMILES string

O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC(CNC(CNC([C@H](CO)NC([C@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC(C3N(CCC3)C(CNC([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](N)CC5=CC=C(C=C5)O)=O)=O)C(C)C)=O)

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Endogenous agonist of neuromedin-U receptor 1 (NMUR1) and neuromedin-U receptor 2 (NMUR2)



Neuromedin U-23 (Neuromedin U), a neuropeptide, is endogenous agonist of neuromedin-U receptor 1 (EC50 = 0.17 nM) and neuromedin-U receptor 2 (EC50 = 1.4 nM) that regulates blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Neuromedin U-23 decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 µg/animal. It appears that neuromedin U regulates epithelial cell differentiation and barrier immunity through interaction with neuromedin-U receptor 1 present at small intestine eosinophils.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000377384
0000377383
0000345800
0000377384
0000377383

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Luca Botticelli et al.
Pharmacological research, 195, 106875-106875 (2023-07-31)
Neuromedin U (NMU) is a bioactive peptide produced in the gut and in the brain, with a role in multiple physiological processes. NMU acts by binding and activating two G protein coupled receptors (GPCR), the NMU receptor 1 (NMU-R1), which
Andrea Peier et al.
Endocrinology, 150(7), 3101-3109 (2009-03-28)
Neuromedin U (NMU) and neuromedin S (NMS) are structurally related neuropeptides that have been reported to modulate energy homeostasis. Pharmacological data have shown that NMU and NMS inhibit food intake when administered centrally and that NMU increases energy expenditure. Additionally
Yu Li et al.
Science (New York, N.Y.), 381(6663), 1189-1196 (2023-09-14)
Eosinophils are granulocytes that play an essential role in type 2 immunity and regulate multiple homeostatic processes in the small intestine (SI). However, the signals that regulate eosinophil activity in the SI at steady state remain poorly understood. Through transcriptome

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