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Merck
CN

SML4033

BI-3812

≥98% (HPLC)

Synonym(s):

1-[5-Chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide, 1-(5-Chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide, 8-(5-Chloro-2-(4-(dimethylamino-formyl)-piperidin-1-yl)-pyrimidin-4-ylamino)-10-methoxy-2-methyl-4-(2-methylamino-2-oxo-ethoxy)-2-aza-bicyclo[4.4.0]deca-1(6),4,7,9-tetraen-3-one, BI 3812, BI3812

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About This Item

Empirical Formula (Hill Notation):
C26H32ClN7O5
CAS Number:
2166387-64-8
Molecular Weight:
558.03
NACRES:
NA.21

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2

Biochem/physiol Actions

Potent and selective BCL6 inhibitor that targets BTB domain with high-affinity.

BI-3812 is a potent and selective BCL6 inhibitor that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay) that inhibits BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM). Unlike BI-3802, BI-3812 does not induce BCL6 proteasomal degradation.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000453623
0000453620
0000453620
0000453623
0000448271

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