SML4033
BI-3812
≥98% (HPLC)
Synonym(s):
1-[5-Chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide, 1-(5-Chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide, 8-(5-Chloro-2-(4-(dimethylamino-formyl)-piperidin-1-yl)-pyrimidin-4-ylamino)-10-methoxy-2-methyl-4-(2-methylamino-2-oxo-ethoxy)-2-aza-bicyclo[4.4.0]deca-1(6),4,7,9-tetraen-3-one, BI 3812, BI3812
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2
Biochem/physiol Actions
BI-3812 is a potent and selective BCL6 inhibitor that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay) that inhibits BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM). Unlike BI-3802, BI-3812 does not induce BCL6 proteasomal degradation.
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