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About This Item
Empirical Formula (Hill Notation):
C11H13BrN3O5P·HCl
CAS Number:
Molecular Weight:
414.58
MDL number:
NACRES:
NA.21
Assay:
≥97%
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥97%
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
SMILES string
BrC1=CC(NC2=O)=C(C(CN[C@@H](P(O)(O)=O)C)=C1)NC2=O.Cl
Biochem/physiol Actions
Potent glycine site-selective NMDA receptor antagonist with anticonvulsant efficacy in vivo.
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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