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About This Item
Empirical Formula (Hill Notation):
C26H31F3N2O3
CAS Number:
Molecular Weight:
476.53
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
BAY-593, a GGTase-I inhibitor, primarily targets the YAP1/TAZ signaling pathway, a crucial axis in cell proliferation and tumor progression. Notably, BAY593 alters the mRNA expression levels of YAP1/TAZ target genes including CYR61, CTCF, ANKRD1, and CD274, indicating its specific molecular action. In vitro studies reveal its IC50 values: 9.41 nM for MDA-MB-231 TEAD-luc, 0.564 µM for MDA-MB-231 proliferation, and 38.4 nM for HT-1080 proliferation. The efficacious in vivo dose was determined as 5 mg/kg (p.o., BID), in the PXF 541 pleuromesothelioma xenograft model, showcasing its therapeutic potential in cancer treatment.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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