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About This Item
Empirical Formula (Hill Notation):
C14H13N3OS3
CAS Number:
Molecular Weight:
335.47
MDL number:
NACRES:
NA.21
SMILES string
CC1=C(CNC(NC2=CC=CS2)=O)SC(C3=CC=CS3)=N1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels.
VU0542270 is a potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels (IC50 ~ 100 nM) that show no apparent activity toward Kir6.2/SUR1 and other members of the Kir channel family. It appears that VU0542270 binds to SUR2. It has a rather short in vivo half-life (t1/2 = 0.64 hour).
VU0542270 is a potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels (IC50 ~ 100 nM) that show no apparent activity toward Kir6.2/SUR1 and other members of the Kir channel family. It appears that VU0542270 binds to SUR2. It has a rather short in vivo half-life (t1/2 = 0.64 hour).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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