Sign In to View Organizational & Contract Pricing
Select a Size
About This Item
Empirical Formula (Hill Notation):
C24H29ClN6O3
CAS Number:
Molecular Weight:
484.98
MDL number:
NACRES:
NA.28
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
SMILES string
CN1C2=CC=C(NC3=NC(N4C[C@H](C[C@H](C4)C)C)=NC=C3Cl)C=C2C=C(C1=O)OCC(NC)=O
Biochem/physiol Actions
Potent and selective BCL6 degrader that targets BTB domain with high-affinity.
BI-3802 is a potent and selective BCL6 degrader that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay). BI-3802 induces BCL6 polymerization (filaments formation) and SIAH1 E3 ligase-mediated ubiquitination, leading to proteasomal degradation (by 80% post 90 min 5 µM treatment in SU-DHL-4 cells) and inhibition of BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM).
BI-3802 is a potent and selective BCL6 degrader that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay). BI-3802 induces BCL6 polymerization (filaments formation) and SIAH1 E3 ligase-mediated ubiquitination, leading to proteasomal degradation (by 80% post 90 min 5 µM treatment in SU-DHL-4 cells) and inhibition of BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM).
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service