Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C20H14Cl3F6N3O3S
CAS Number:
Molecular Weight:
596.76
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
FC(F)(F)[C@@]2(ONC(=C2)c3[s]c(c(c3)C)C(=O)NCC(=O)NCC(F)(F)F)c1cc(c(c(c1)Cl)Cl)Cl
InChI
1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-5,32H,6-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
InChI key
DPFOXZCPAGCTER-SFHVURJKSA-N
Biochem/physiol Actions
Orally available and potent inhibitor of γ-aminobutyric acid (GABA)-gated chloride channels; parasiticide.
Lotilaner is an oral isooxazoline ectoparasitic veterinary medication used to control fleas and ticks in dogs and cats. Lotilaner, similarly to other isoxazolines, targets gamma-aminobutyric acid (GABA) receptors. It binds to the GABA-gated chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals and leads to paralysis and death.
Lotilaner is an oral isooxazoline ectoparasitic veterinary medication used to control fleas and ticks in dogs and cats. Lotilaner, similarly to other isoxazolines, targets gamma-aminobutyric acid (GABA) receptors. It binds to the GABA-gated chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals and leads to paralysis and death.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
The novel isoxazoline ectoparasiticide lotilaner (Credelio?): a non-competitive antagonist specific to invertebrates ?-aminobutyric acid-gated chloride channels (GABACls).
Parasites & vectors, 10(1), 530-530 (2017)
Ian Benjamin Gaddie et al.
Ophthalmology, 130(10), 1015-1023 (2023-06-08)
To evaluate the safety and efficacy of lotilaner ophthalmic solution 0.25% compared with vehicle for the treatment of Demodex blepharitis. Prospective, randomized, double-masked, vehicle-controlled, multicenter, phase 3 clinical trial. Four hundred twelve patients with Demodex blepharitis were assigned randomly in
Omar Hashim et al.
Molecular pharmacology, 102(2), 116-127 (2022-07-21)
Human louse Pediculus humanus is a cosmopolitan obligatory blood-feeding ectoparasite causing pediculosis and transmitting many bacterial pathogens. Control of infestation is difficult due to the developed resistance to insecticides that mainly target GABA (γ-aminobutyric acid) receptors. Previous work showed that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML4081-25MG | 04065272112383 |
| SML4081-5MG | 04065272112390 |