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About This Item
Empirical Formula (Hill Notation):
C39H57FN4O4
CAS Number:
Molecular Weight:
664.89
MDL number:
NACRES:
NA.21
SMILES string
Fc1cc2[o]nc(c2cc1)C3CCN(CC3)CCC4=C(NC5=C(CCCN5C4=O)OC(=O)CCCCCCCCCCCCCCC)C
InChI key
YOSKWMGLLZWACB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
soluble (DMSO:TFA, 2 mg/mL, clear (add 1 drop TFA))
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Prodrug form of paliperidone, is a long-acting injectable antipsychotic that targets dopamine and serotonin receptors.
Paliperidone palmitate is a long-acting injectable form of paliperidone, an atypical antipsychotic that targets dopamine D2 and serotonin 5-HT2A receptors to alleviate schizophrenia symptoms through neurotransmission regulation. Paliperidone palmitate also interacts with α1/α2 adrenergic and H1 histaminergic receptors, influencing both its therapeutic effects and side effect profile. The formulation′s sustained release mechanism promotes gradual absorption, ensuring stable drug levels for prolonged efficacy.
Paliperidone palmitate is a long-acting injectable form of paliperidone, an atypical antipsychotic that targets dopamine D2 and serotonin 5-HT2A receptors to alleviate schizophrenia symptoms through neurotransmission regulation. Paliperidone palmitate also interacts with α1/α2 adrenergic and H1 histaminergic receptors, influencing both its therapeutic effects and side effect profile. The formulation′s sustained release mechanism promotes gradual absorption, ensuring stable drug levels for prolonged efficacy.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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L E van Beijsterveldt et al.
Psychopharmacology, 114(1), 53-62 (1994-02-01)
Risperidone is a new benzisoxazole antipsychotic. 9-Hydroxy-risperidone is the major plasma metabolite of risperidone. The pharmacological properties of 9-hydroxy-risperidone were studied and appeared to be comparable to those of risperidone itself, both in respect of the profile of interactions with
Dean Najarian et al.
The international journal of neuropsychopharmacology, 25(3), 238-251 (2021-11-19)
This double-blind (DB), randomized, parallel-group study was designed to evaluate efficacy and safety of paliperidone palmitate 6-month (PP6M) formulation relative to paliperidone palmitate 3-month (PP3M) formulation in patients with schizophrenia. Following screening, patients entered an open-label (OL) maintenance phase and
Paliperidone palmitate vs. paliperidone extended-release for the acute treatment of adults with schizophrenia: a systematic review and pairwise and network meta-analysis
Translational Psychiatry, 12(1), 519-519 (2022)
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