SML4084
N6-Furfuryladenosine
≥98% (HPLC)
Synonym(s):
Kinetin riboside, Ribosylkinetin, NSC 120958, N-(2-Furanylmethyl)-adenosine, 6-Furfurylaminopurine riboside
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About This Item
Empirical Formula (Hill Notation):
C15H17N5O5
CAS Number:
Molecular Weight:
347.33
MDL number:
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O[C@@]1([C@@]([H])([C@]([H])(O[C@@]1([H])N2C=NC3=C2N=CN=C3NCC4=CC=CO4)CO)O)[H]
Biochem/physiol Actions
Naturally occurring purine nucleoside analog that protect cells against oxidative stress.
N6-Furfuryladenosine (Kinetin riboside) is a purine nucleoside analog. It is a naturally occurring plant cytokine and a product of oxidative DNA damage. N6-Furfuryladenosine protect cells against oxidative stress and delay of age-related phenotypes in human fibroblasts. N6-furfuryladenosine enhances mitochondrial turnover and bioenergetics in the diabetic mouse retina (Ins2Akita males). N6-Furfuryladenosine displays strong antiproliferative activity in various human cancer cells.
N6-Furfuryladenosine (Kinetin riboside) is a purine nucleoside analog. It is a naturally occurring plant cytokine and a product of oxidative DNA damage. N6-Furfuryladenosine protect cells against oxidative stress and delay of age-related phenotypes in human fibroblasts. N6-furfuryladenosine enhances mitochondrial turnover and bioenergetics in the diabetic mouse retina (Ins2Akita males). N6-Furfuryladenosine displays strong antiproliferative activity in various human cancer cells.
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Ewa Totoń et al.
Bioorganic & medicinal chemistry letters, 100, 129628-129628 (2024-01-28)
N6-[(Furan-2-yl)methyl]adenosine (kinetin riboside) and its seven synthesized analogues were examined for the ability to inhibit the growth of five human carcinoma cell lines and for comparison of normal human lung fibroblast cell line (MRC-5). Out of the compounds evaluated, 8-azakinetin
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status
Anderson A, et al.
Nature Communications, 15 (2024)
TaeKyung Nam et al.
Journal of microbiology and biotechnology, 33(9), 1206-1212 (2023-07-19)
Kinetin riboside is a naturally produced cytokinin that displays strong antiproliferative activity in various human cancer cells. However, the mechanism of chemoprevention in colorectal cancer cells has not been elucidated. We used a cell-based reporter system to identify kinetin riboside
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