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About This Item
Empirical Formula (Hill Notation):
C24H24N4S · xHBr
Molecular Weight:
400.54 (free base basis)
NACRES:
NA.21
Assay:
>98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Selective transient receptor potential cation channel TRPV4 blocker in cultures and in vivo.
GSK205 is a selective transient receptor potential cation channel TRPV4 blocker that prevents hyposmotic stress-, as well as TRPV4 activator 4αPDD-induced Ca2+ response (IC50 = 600 nM against 10 µM 4αPDD (EC50 = 2 µM); porcine articular chondrocytes). GSK205 upregulates the expression of thermogenic genes in 3T3-F442A adipocyte cultures (5 µM for 4 days) and in diet-induced obese (DIO) mice in vivo (10 mg/kg b.i.d. i.p.)
GSK205 is a selective transient receptor potential cation channel TRPV4 blocker that prevents hyposmotic stress-, as well as TRPV4 activator 4αPDD-induced Ca2+ response (IC50 = 600 nM against 10 µM 4αPDD (EC50 = 2 µM); porcine articular chondrocytes). GSK205 upregulates the expression of thermogenic genes in 3T3-F442A adipocyte cultures (5 µM for 4 days) and in diet-induced obese (DIO) mice in vivo (10 mg/kg b.i.d. i.p.)
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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