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About This Item
Empirical Formula (Hill Notation):
C17H19F2N5O2S
CAS Number:
Molecular Weight:
395.43
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352203
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=C(/C=N/NC(NC(C)(C)C)=S)N(C2=CC=C(C=C2F)F)N=C1)OC
Biochem/physiol Actions
Potent and human GPR35-selective antagonist that effectively blocks agonist-induced cellular responses without significant effect toward rat or mouse GPR35.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
CID 2745687 is a potent and human GPR35-selective antagonist that effectively blocks agonist pamoic acid (PA)-induced cellular responses using human HA-GPR35a-expressing U2OS transfectants (Ki = 12.8 or 18 nM against 1 µM PA by βarr2-GFP recruitment and ERK1/2 phosphorylation, respectively), while exhibiting no significant effect toward rat or mouse GPR35. CID 2745687 is competitive against cromolyn disodium and zaprinast, while being noncompetitive against PA.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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