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Merck
CN

SML4113

OGT2115

≥97% (HPLC)

Synonym(s):

2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid, 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid, OGT 2115, OGT-2115

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About This Item

Empirical Formula (Hill Notation):
C24H16BrFN2O4
CAS Number:
853929-59-6
Molecular Weight:
495.30
MDL number:
MFCD12828743
NACRES:
NA.28
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

soluble (DMSO:0.1M NaOH (95:5), 1.0 mg/mL, clear, warmed, may need to sonicate.)

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Heparanase (HPSE) inhibitor with anti-angiogenesis potency and no inhibition of major human cytochrome P450 enzymes.

OGT 2115 is a heparanase (HPSE) inhibitor (IC50 = 0.4 μM) with anti-angiogenesis potency in human endothelial cell cultures (tubule formation IC50 = 1 μM) and no inhibition of major human cytochrome P450 enzymes (Cyp3A4 & Cyp2C9 IC50 > 30 μM).

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000401445
0000401445

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