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About This Item
Empirical Formula (Hill Notation):
C26H43NO2
CAS Number:
Molecular Weight:
401.63
MDL number:
NACRES:
NA.28
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
SMILES string
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N(C)C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
Biochem/physiol Actions
Orally active liver X receptor LXRα/β agonist that selectively induces ABCA1 gene transcriptional activation over that of SREBP-1c in vitro and in vivo.
DMHCA, a synthetic oxysterol, is an orally active liver X receptor (LXR) agonist (LXRα/β EC50 = 2 µM by reporter assays using respective CV-1 transfectants; LXRα/β Ki = 130/100 nM) that, unlike GW3965 & T0901317, preferentially induces ATP-binding cassette transporter ABCA1 gene transcriptional activation over that of SREBP-1c both in vitro and in mice in vivo. Long-term DMHCA administration significantly reduces lesion formation in male and female apoE-deficient mice (80 mg/kg/day via chow diet) without increasing hepatic triglyceride (TG) levels.
DMHCA, a synthetic oxysterol, is an orally active liver X receptor (LXR) agonist (LXRα/β EC50 = 2 µM by reporter assays using respective CV-1 transfectants; LXRα/β Ki = 130/100 nM) that, unlike GW3965 & T0901317, preferentially induces ATP-binding cassette transporter ABCA1 gene transcriptional activation over that of SREBP-1c both in vitro and in mice in vivo. Long-term DMHCA administration significantly reduces lesion formation in male and female apoE-deficient mice (80 mg/kg/day via chow diet) without increasing hepatic triglyceride (TG) levels.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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