SML4120
BIBP3226 trifluoroacetate
≥95% (HPLC)
Synonym(s):
BIBP 3226 TFA salt, BIBP-3226 TFA salt, Diphenylacetyl-D-Arg-4-hydroxybenzylamide, trifluoroacetate salt, N2-(Diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide, trifluoroacetate salt, (R)-N2-(Diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-argininamide, trifluoroacetate salt
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About This Item
Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O
Biochem/physiol Actions
BIBP3226 is a potent and selective non-peptide neuropeptide Y receptor Y1 antagonist (Ki = 7 nM against neuropeptide Y binding to receptor Y1) in vitro and in vivo. BIBP3226 selectively blocks Y1 receptor-mediated rabbit saphenous vein contraction (pA2 = 7.36), but not receptor Y2- or Y3-dependent biological effects.
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