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Merck
CN

SML4124

Ginsenoside Rb2

≥98% (HPLC)

Synonym(s):

(3β,12β)-20-[(6-O-α-L-Arabinopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside, G-Rb2, Ginsenoside C, NSC 308878

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About This Item

Empirical Formula (Hill Notation):
C53H90O22
CAS Number:
Molecular Weight:
1079.27
MDL number:
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@@](CCC=C(C)C)(C)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO[C@H]8

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Biochem/physiol Actions

Ginsenoside Rb2 exhibits diverse biological activities through interaction with various cellular receptors

Ginsenoside Rb2, a steroid glycoside found in Panax ginseng, demonstrates diverse biological activities. Exhibits adaptogenic properties, functions as an antioxidant, possesses anti-inflammatory, antidiabetic, antitumor, anti-osteoporosis and antimetastatic characteristics, provides neuroprotective effects, and acts as an immune modulator. Ginsenoside-Rb2 exerts modulation on various signaling pathways, including PI3K/Akt, MAPK, Nrf2/HO-1, Wnt/β-catenin, and AMPK pathways. Additionally, G-Rb2 activates SIRT-1 while antagonizing P2Y12R.

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