Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C13H12N4S
CAS Number:
Molecular Weight:
256.33
NACRES:
NA.28
SMILES string
C1(SC(N2CCC(NC=N3)=C3C2)=N4)=C4C=CC=C1
assay
≥98%
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Restores ATG9A function and modulates intracellular trafficking and autophagy.
BCH-HSP-C01, a novel pharmacotherapeutic agent, is engineered to rectify ATG9A-related pathologies. Its primary mode of action entails the regulation of intracellular trafficking mechanisms, with a pronounced effect on the RAB protein family, integral to vesicular transport processes. Exhibiting both temporal and concentration-dependent characteristics, BCH-HSP-C01 optimally enhances ATG9A translocation within a 72–96 hour window post-administration, achieving an EC50 ~ 5 µM in hiPSC-derived neurons from AP-4-HSP patients. Furthermore, BCH-HSP-C01 markedly increases autophagic flux, as indicated by the elevated levels of LC3-II following its application and restores neuronal phenotypes of adapter protein complex 4 (AP-4)-deficiency.
BCH-HSP-C01, a novel pharmacotherapeutic agent, is engineered to rectify ATG9A-related pathologies. Its primary mode of action entails the regulation of intracellular trafficking mechanisms, with a pronounced effect on the RAB protein family, integral to vesicular transport processes. Exhibiting both temporal and concentration-dependent characteristics, BCH-HSP-C01 optimally enhances ATG9A translocation within a 72–96 hour window post-administration, achieving an EC50 ~ 5 µM in hiPSC-derived neurons from AP-4-HSP patients. Furthermore, BCH-HSP-C01 markedly increases autophagic flux, as indicated by the elevated levels of LC3-II following its application and restores neuronal phenotypes of adapter protein complex 4 (AP-4)-deficiency.
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service