Detomidine

Detomidine may be used in the research field foranimal behavior studies to facilitate sedation and to conduct procedures thatneed immobilization of animals for observation.

Detomidine is an α2-adrenergic receptor(α2-adrenoceptor) agonist with in vivo sedative and analgesic efficacy.In receptor binding experiments, detomidine showed strong affinity to alpha2-receptors. There was some binding affinity towards alpha 1-receptors also butonly negligible or no affinity towards dopamine, opiate and adenosinereceptors. Detomidine is a derivative of imidazole that exerts muscle relaxation effects. It also acts as an anesthetic adjunct. Detomidine also shows cardiovascular effectssuch as induction of a state of hypertension, bradycardia and increasedsystemic and pulmonary vascular resistance.(4)