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About This Item
Empirical Formula (Hill Notation):
C12H14N2
CAS Number:
Molecular Weight:
186.25
MDL number:
NACRES:
NA.21
SMILES string
CC1=C(C=CC=C1C)CC2=CN=CN2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Application
Detomidine may be used in the research field foranimal behavior studies to facilitate sedation and to conduct procedures thatneed immobilization of animals for observation.
Biochem/physiol Actions
Detomidine is an α2-adrenergic receptor(α2-adrenoceptor) agonist with in vivo sedative and analgesic efficacy.In receptor binding experiments, detomidine showed strong affinity to alpha2-receptors. There was some binding affinity towards alpha 1-receptors also butonly negligible or no affinity towards dopamine, opiate and adenosinereceptors. Detomidine is a derivative of imidazole that exerts muscle relaxation effects. It also acts as an anesthetic adjunct. Detomidine also shows cardiovascular effectssuch as induction of a state of hypertension, bradycardia and increasedsystemic and pulmonary vascular resistance.(4)
Regulatory Information
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