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About This Item
Assay:
≥98% (HPLC)
Form:
solution
Quality Segment
assay
≥98% (HPLC)
form
solution
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
FINO2 is used as aresearch tool to study pathways of ferroptosis and to probe explore how thesepathways relate to diseases including Alzheimer’s, Parkinson’s andcardiovascular diseases.
Biochem/physiol Actions
FINO2 is a novel inducer of ferroptosis. It acts in a different manner than class 1 inducers, which deplete glutathione by inhibiting cystine import via system xc−, or class 2 inihbitors, which covalently inhibit glutathione peroxidase 4 (GPX4). FINO2 has a two-fold mechanism of action. It indirectly inhibits the enzymatic of glutathione peroxidase 4 (GPX4) and directly oxidizes iron, leading to widespread lipid peroxidation and eventual cell death. FINO2 was found to be more potent in cancer cells than in nonmalignant cells of the same type.
signalword
Danger
hcodes
Hazard Classifications
Org. Perox. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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