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About This Item
Empirical Formula (Hill Notation):
C15H28O3
CAS Number:
Molecular Weight:
256.38
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
FINO2 is used as aresearch tool to study pathways of ferroptosis and to probe explore how thesepathways relate to diseases including Alzheimer’s, Parkinson’s andcardiovascular diseases.
Biochem/physiol Actions
FINO2 is a lipophilic compound , and a novel inducer of ferroptosis. It acts in a different manner than class 1 inducers, which deplete glutathione by inhibiting cystine import via system xc−, or class 2 inihbitors inhibitors, which covalently inhibit glutathione peroxidase 4 (GPX4). FINO2 has a two-fold mechanism of action. It indirectly inhibits the enzymatic activity of glutathione peroxidase 4 (GPX4) and directly oxidizes iron, leading to widespread lipid peroxidation and eventual cell death. FINO2 is found to be more potent in cancer cells than in non-malignant cells of the same type.
signalword
Danger
hcodes
Hazard Classifications
Org. Perox. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML4157-5MG | 04065272636919 |
| SML4157-25MG | 04065272635608 |
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